January 20, 2016

Gene Therapy for Cartilage Regeneration

By Dave Hansen


Christopher H. Evans, Ph.D., Director of Mayo Clinic Rehabilitation Medicine Research Center, Professor of Orthopedics and Carmen Terzic, M.D., Ph.D., Chair of Mayo Clinic Physical Medicine and Rehabilitation discuss Gene Therapy for Cartilage at the Fourth Annual Symposium on Regenerative Rehabilitation.

Cartilage is unusual tissue because it’s one of the few organs in the body that has no ability to repair itself after injury.

It is frequently injured in sporting activities and accidents, and is damaged by diseases such as arthritis.

Dr. Evans believes it’s important to be inventive when developing ways to repair cartilage.

The approach the RMRC uses is to develop technologies that can be implemented in the operating room in a single procedure; nothing has to leave or be grown outside the body.

Watch the video as Dr. Evans talks about how gene transfer is used in a single surgery without the need to groom the cells.


Tags: @mayoclinicpmr, bing.com, carmen terzic, cartilage, Christopher Evans, Education, fourth annual symposium on regenerative rehabilitation, gene therapy., google.com, Mayo Clinic, spine, spinal, sci, rochester, mn, mn, physical medicine, PMR, rehabiliation medicine research center, Research, rmrc, rochester, sci, spinal, spine, trauma and arthritis, yahoo.com

Is there any research/trials in the immediate future for hand/thumb/wrist arthritis? I’m an artist, clay and pastel, 67 and I’m afraid I will soon not be able to do either. Thank you. Nancy N.


Is there any research/trials in the immediate future for hand/thumb/wrist arthritis? I’m an artist, clay and pastel, 67 and I’m afraid I will soon not be able to do either. Thank you. Nancy N.

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Hi, Nancy. Thank you for your interest in clinical trials. I’ve enclosed links that may assist you in findings studies as they become posted and would be available to you.

Mayo Clinic Clinical Trials: http://clinicaltrials.mayo.edu/ you may search by location/condition/healthy volunteer etc. (you may need to fill out some information about yourself i.e.: gender/age). Once you find a study that you would be interested in participating in, there will be a phone number and/or email to contact a study coordinator who will then go thru the eligibility and any remuneration with you. I have found the following studies which may be of interest to you http://www.mayo.edu/research/clinical-trials/search-results?keyword=Thumb%20arthritis&status=open-unknown .

Please be aware that Clinical studies differ from medical care. When you visit your doctor, he or she diagnoses and treats your current illness or condition. During clinical studies, researchers are trying to gather new knowledge that will help them improve medical care for people in the future. You may also like to call our Regenerative Medicine Consult Service – for general information and appointments Toll Free: 844-276-2003.

I would also recommend searching the National Institutes of Health-Clinical Trials website at http://clinicaltrials.gov . It is a large database containing information about research throughout the world. You can search for keywords as well as view specific study summaries. Each study will then list criteria for that particular study and contact information.

You may also like to register on line at https://www.researchmatch.org/ this is a site that brings both volunteers and researchers together.

I hope you find this information helpful.


Margaret, I will research all. I’m not confident in the potential outcomes of the “tried and true” surgeries for arthritic thumbs and am hoping to find other applicable therapies. Stem cell research looks promising. I appreciate your response. Thank you. Nancy

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