Researchers at Mayo Clinic recently published the results of a study to assess whether sleep-disordered breathing affects the peripheral circulation, decreases perfusion as measured by TcPO2 and decreases the odds that a partial-foot amputation site will heal. Obstructive sleep apnea (OSA) is a risk factor for hypertension, cerebral artery stenosis, stroke and hypercoagulability. The researchers hypothesized that it would be an independent risk factor causing delayed healing of partial-foot amputations.
The study was a retrospective, observational study on 307 patients, who had TcPO2 measurements and had undergone a partial-foot amputation. Of those 307 patients, 25 had obstructive sleep apnea. These patients actually had a 3.7-fold increase in odds of healing within three months in comparison with patients without obstructive sleep apnea. Of note, 16 patients (64 percent) with the condition were not treated with continuous positive airway pressure (CPAP) and healed within three months.
The results did not support the hypothesis that the presence of sleep apnea may impair healing of partial foot amputations. The researchers note that further studies are needed to determine the full effect of obstructive sleep apnea and its treatment on TcPO2s and healing.
See PubMed for the full study.