Dec 26, 2014 · Leave a Reply

Regenerative Principles Enrich Cardiac Rehabilitation

By dehansen @dhansen

The November 2014 supplement to the American Journal of Physical Medicine & Rehabilitation is focused on regenerative rehabilitation.

One of three reports authored by Mayo Clinic physicians, researchers examined cardiac rehabilitation.

Atta Behfar, M.D., Ph.D.,  Cardiovascular Diseases, Assistant Professor of Medicine,     College of Medicine

Atta Behfar, M.D., Ph.D., Cardiovascular Diseases, Assistant Professor of Medicine,
College of Medicine

Carmen Terzic, M.D., Ph.D., Chair, Physical Medicine & Rehabilitation Mayo Clinic

Carmen Terzic, M.D., Ph.D., Chair, Physical Medicine & Rehabilitation Mayo Clinic

Andre Terzic, M.D., Ph.D., Cardiovascular Diseases, Professor of Medicine and Pharmacology, Mayo Clinic College of Medicine

Andre Terzic, M.D., Ph.D., Cardiovascular Diseases, Professor of Medicine and Pharmacology, Mayo Clinic College of Medicine

Cardiovascular morbidity imposes a high degree of disability and mortality, with limited therapeutic options available in end-stage disease.

Integral to standard of care, cardiac rehabilitation aims on improving quality-of-life and prolonging survival.

The recent advent of regenerative technologies paves the way for a transformative era in rehabilitation medicine whereby, beyond controlling risk factors and disease progression, the prospect of curative solutions is increasingly tangible.

To date, the spectrum of clinical experience in cardiac regenerative medicine relies on stem cell–based therapies delivered to the diseased myocardium either acutely/sub-acutely, after a coronary event, or in the setting of chronic heart failure.

mayo_pmr_blog_cardioimage

Application of autologous/allogeneic stem cell platforms has established safety and feasibility, with encouraging signals of efficacy.

Newer protocols aim to purify cell populations in an attempt to eliminate non-regenerative and enrich for regenerative cell types before use.

Most advanced technologies have been developed to isolate resident cell populations directly from the heart or, alternatively, condition cells from non-cardiac sources to attain a disease-targeted lineage-specified phenotype for optimized outcome.

Because a multiplicity of cell-based technologies has undergone phase I/II evaluation, pivotal trials are currently underway in larger patient populations. Translation of regenerative principles into clinical practice will increasingly involve rehabilitation providers across the continuum of patient care.

Regenerative rehabilitation is thus an emerging multidisciplinary field, full of opportunities and ready to be explored.

Use this link to access the full AJPMR supplement article.

Tags: @mayoclinicpmr, cardiac, cardio, coronary, Education, endomyocardial, heart, intracoronary, mayo, Mayo Clinic, spine, spinal, sci, rochester, mn, mn, physical medicine, quality of life, rehabilitation, Research, rochester, sci, spinal, spine, stem cell, terzic, Uncategorized

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